- The presence of hypophosphatemia due to inadequate intake is unusual since phosphorus is a chemical element with the symbol P and atomic number 15 and is found in small amounts in food.
- Elemental phosphorus comes in two primary forms: white phosphorus and red phosphorus.
- However, because to the extreme reactivity of phosphorus, it is never found as a free element on the surface of the Earth.
- It is found in high concentration in the Earth’s crust and is abundant in the human diet.
- It can occur, though, when a person has been chronically and severely malnourished for an extended period of time.
- Inflammatory conditions, surgery, and diarrhea are all known to cause phosphorus malabsorption in certain people.
- A persistent alcoholism is the most prevalent cause of hypophosphatemia, and it is also the most preventable.
Patients with hypophosphatemia are normally asymptomatic, and it can be seen in up to 5 percent of the population. It is far more common among those suffering from alcoholism, diabetic ketoacidosis, or sepsis, with a frequency of up to 80% in these situations. The severity and etiology of hypophosphatemia have a significant impact on the morbidity associated with the condition.
What is the prognosis of hypophosphatemia with phosphate depletion?
It is frequent in the hospital context to have acute hypophosphatemia along with phosphate depletion, which leads in considerable morbidity and death. Children and adults with chronic hypophosphatemia, which is frequently linked with hereditary or acquired renal phosphate-wasting diseases, typically experience aberrant development and rickets, as well as osteomalacia.
What is the difference between acute and chronic hypophosphatemia?
Acute hypophosphatemia is more common than chronic hypophosphatemia. It is frequent in the hospital context to have acute hypophosphatemia along with phosphate depletion, which leads in considerable morbidity and death. Chronic hypophosphatemia, which is frequently linked with hereditary or acquired renal phosphate-wasting diseases, is characterized by the presence of a…
Is low phosphate common?
Hypophosphatemia is an uncommon condition in the general population. People who are hospitalized or admitted to critical care units are more likely to be affected by this condition (ICUs). People hospitalized to hospitals with this illness account for between 2 percent and 3 percent of all patients, and up to 34 percent of those in intensive care units.
What is the most common cause of hypophosphatemia?
Alcoholism that has persisted over a long period of time. The presence of this condition is one of the most prevalent reasons of hypophosphatemia. Hypophosphatemia develops in 50% of persons who are admitted to the hospital because of alcoholism within the first three days of their admission.
Who is at risk for hypophosphatemia?
Individuals who are admitted to the hospital are more likely to suffer from this condition. This syndrome is more likely to affect people who are malnourished as a result of eating disorders, drunkenness, or long-term diarrhea, among other factors. People who have had serious burns or who have diabetic problems are also at risk.
Can hypophosphatemia cause death?
Acute severe hypophosphatemia can result in severe neuromuscular abnormalities, rhabdomyolysis, convulsions, coma, and death if not treated promptly.
Is hypophosphatemia the same as hypophosphatasia?
Hypophosphatemia is spelled similarly to hypophosphatasia, however it refers to low amounts of phosphate in the blood. Rickets/osteomalacia caused by X-linked hypophosphatemia is the most frequent kind of hereditary rickets/osteomalacia. It is characterized by the kidneys’ failure to activate vitamin D and keep phosphate out of the urine and in the blood stream.
How do you fix hypophosphatemia?
One must cure any precipitating factors of hypophosphatemia while also replacing total body phosphates in order to treat hypophosphatemia effectively on both fronts. Replacement alternatives for phosphate include dietary phosphate, oral phosphate preparations, and intravenous phosphate, depending on the clinical condition.
What kind of doctor treats hypophosphatemia?
A nephrologist can assist in determining the possibility of phosphate wasting in a patient as well as evaluating the patient for potential reasons of renal phosphorus wasting.
What drugs cause hypophosphatemia?
It is common to have hypophosphatemia, which is defined as blood phosphate levels less than 2.5 milligrams per deciliter (0.81 millimoles per liter), during the course of therapy with regularly prescribed medications such as diuretics, bisphosphonates, antibiotics, insulin, and antacids.
What is considered severe hypophosphatemia?
Hypophosphatemia is classified as mild (2-2.5 mg/dL, or 0.65-0.81 mmol/L), moderate (1-2 mg/dL, or 0.32-0.65 mmol/L), or severe (less than 1 mg/dL, or 0.32 mmol/L) depending on the severity of the condition. Hypophosphatemia, ranging from mild to very severe, is frequently asymptomatic. Severe hypophosphatemia, on the other hand, is associated with significant clinical consequences.
What is familial hypophosphatemia?
Depending on the severity of the hypophosphatemia, it is classified as mild (2-2.5 mg/dL, or 0.665-0.81 mmol/L), moderate (1-2 mg/dL, or 0.332-0.65 mmol/L), or severe ( 1 mg/dL, 0.32 mmol/L). Low phosphate levels, ranging from mild to highly severe, are frequently undetectable. Severe hypophosphatemia is frequently associated with significant clinical consequences.
Can hyperphosphatemia cause seizures?
– The manifestations of hyperphosphatemia are related to the hypocalcemia that results as a result of the condition. There have been reports of cardiovascular failure, convulsions, and coma. Hypophosphatemia is characterized by the depletion of energy (ATP), which can result in weariness and malfunction of organs with a high metabolic activity.
Why do we get hypophosphatemia?
Low phosphate intake over a long period of time combined with an abrupt rise in intracellular phosphate needs (such as happens with refeeding) is the most common cause of hypophosphatemia in humans. A poor diet combined with intestinal malabsorption might result in insufficient phosphate intake, which is particularly dangerous.
What is refeed syndrome?
Low phosphate intake over a long period of time combined with an abrupt rise in intracellular phosphate needs (such as occurs during refeeding) is the most common cause of hypophosphatemia in humans. A poor diet combined with intestinal malabsorption might result in insufficient phosphate intake, which can be dangerous.
What is hyperphosphatemia?
Hyperphosphatemia, or excessively high blood phosphate levels, can occur as a result of increased phosphate consumption, reduced phosphate excretion, or as a result of a condition that causes intracellular phosphate to be released into the extracellular space, among other causes. Even severe hyperphosphatemia, on the other hand, is mostly asymptomatic in the clinical setting.